This course is a free, online, asynchronous lecture series available to participants around the world. The course covers the fundamentals of clinical pharmacology as a translational scientific discipline grounded in pharmacokinetics and core pharmacologic principles. It emphasizes key concepts in pharmacokinetics, drug metabolism and transport, drug therapy in special populations, pharmacogenomics, and drug discovery and development. The course is designed for graduate students, postdoctoral scholars, medical and pharmacy students, scientists, and health professionals seeking to strengthen their understanding of pharmacologic principles.